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This virtual seminar series addresses a wide range of current topics in Fragile X research. Hosted by FRAXA and organized by Michael Tranfaglia, MD and Patricia Cogram, PhD, sessions feature outstanding speakers from universities and the biotech and pharmaceutical industries. ---- Presentation Abstract ---- Dr. Jin will discuss why they chose to use brain organoids to study the function of FMRP. Dr. Zhexing will then introduce their organoid system and describe the phenotypes associated with Fragile X organoids. Finally, Dr. Jin will present their molecular analyses of FMRP mRNA targets in humans as well as future direction for the newly funded Fragile X Center of Excellence at Emory University School of Medicine. ---- Speakers ---- Zhexing Wen, PhD Associate Director of Psychiatric, Genetics and Epigenetics Core Emory University School of Medicine Peng Jin, PhD Professor and Chair, Department of Human Genetics Emory University School of Medicine ---- Timestamps ---- 0:00 Intro with Dr. Michael Tranfaglia 1:49 Modeling FXS with Human iPSC-derived Brain Organoids 34:14 Identification of Human FMRP mRNA targets 51:54 FMRP-mediated Regulation in Human Brain Development and Therapeutic Advancement 1:04:00 Questions and Answers 1:14:43 Closing remarks ---- About FRAXA ---- FRAXA’s mission is to find effective treatments and ultimately a cure for Fragile X syndrome. We directly fund research grants and fellowships at top universities around the world. We partner with biomedical and pharmaceutical companies, large and small, to bridge the gap between research discoveries and actual treatments. Treatments for Fragile X are likely to help people affected by autism, Alzheimer’s, and other brain disorders. To learn more about FRAXA's Fragile X syndrome research, to get involved with Fragile X awareness and events or to donate to FRAXA research, visit www.fraxa.org Let's Connect Facebook: / fraxaresearch Instagram: / fraxaresearch LinkedIn: / fraxa-research-foundation Twitter: / fraxaresearch Website: https://www.fraxa.org