Role of UHRFI in cancer therapies - Video Abstract ID 192234 скачать в хорошем качестве

Role of UHRFI in cancer therapies - Video Abstract ID 192234

Video abstract of Review paper “Epigenetic mechanism and target therapyof UHRF1 protein complex in malignancies” published in the open access journal OncoTargets and Therapy by authors Xue B, Zhao J, Feng PH, et al. Ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 (UHRF1) functions as an epigenetic regulator recruiting PCNA, DNMT1, histone deacetylase 1, G9a, SuV39H, herpes virus-associated ubiquitin-specific protease, and Tatinteractive protein by multiple corresponding domains of DNA and H3 to maintain DNA methylation and histone modifications. Overexpression of UHRF1 has been found as a potential biomarker in various cancers resulting in either DNA hypermethylation or global DNA hypomethylation, which participates in the occurrence, progression, and invasion of cancer. The role of UHRF1 in the reciprocal interaction between DNA methylation and histone modifications, the dynamic structural transformation of UHRF1 protein within epigenetic code replication machinery in epigenetic regulations, as well as modifications during cell cycle and chemotherapy targeting UHRF1 are evaluated in this study. Read the full paper here https://www.dovepress.com/epigenetic-...