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📌Get your "Prednisone Checklist" today: https://prednisonepharmacist.com/pred... This video compares two powerful glucocorticoids: dexamethasone and prednisone. Learn how they differ in potency, duration, dosing, and side effects. Whether you're dealing with an acute emergency or managing a chronic condition, understanding the strengths and risks of each steroid is key to better treatment decisions. This video breaks it all down—when one is preferred over the other, what to watch for in terms of side effects, and how they interact with different receptors in the body. Key Takeaways: 1. Potency and Dosing: Dexamethasone is much stronger than prednisone—just 0.75 mg of dexamethasone equals 5 mg of prednisone. 2. Duration of Action: Dexamethasone lasts longer (36–72 hours) than prednisone (18–22 hours), making it better for acute conditions that need sustained action. 3. When They're Used: Dexamethasone is typically used for emergencies like brain swelling or severe asthma, while prednisone is used for ongoing issues like lupus or arthritis. 4. Side Effects: Dexamethasone may cause stronger psychiatric effects, blood sugar spikes, and muscle weakness. Prednisone is more associated with fluid retention, weight gain, and stomach problems, especially long term. 5. Receptor Differences: Dexamethasone mainly targets glucocorticoid receptors. Prednisone also affects mineralocorticoid receptors, which can lead to fluid and electrolyte imbalances. - Dr. Megan is the Prednisone Pharmacist who experienced side effects from a prescription drug called prednisone. Here she teaches tips to deal with side effects naturally. Every week Dr. Megan posts a new video with an answer to your burning prednisone questions. ✅ Get your Prednisone Checklist for the Top 7 Mistakes prednisone users make, plus 15 ways to counteract prednisone side effects: https://prednisonepharmacist.com/pred... Need a way to give back what prednisone steals? Dr. Megan invented Nutranize Zone, which contains the 10 nutrients prednisone steals. The only supplement you need while on prednisone. https://nutranize.com/ Learn more at Dr. Megan's website with videos posted as in-depth blogs at prednisonepharmacist.com Follow Dr. Megan! Facebook: facebook.com/prednisonepharmacist Instagram: @prednisonepharmacist Book an appointment with Dr. Megan at https://calendly.com/prednisone/1 Write me! Dr. Megan 1400 Chapel St #343 Santa Clara, UT 84738 #prednisone #prednisonesideeffects #steroids #steroidsideeffects #glucocorticoid #dexamethasone #corticosteroids #drugcomparison #medicaldecision #patienteducation