Jian Han - GoldLab Symposium 2019 скачать в хорошем качестве

Jian Han - GoldLab Symposium 2019

The process of developing a diagnostic is slow and expensive because identifying disease signal requires knowledge, and detecting the signal relies on technologies. A shortcut to this classical approach is to learn from the best doctor in the world, i.e., our immune system. In nature, our immune system has already acquired the skills to diagnose and treat diseases. Each of our immune cells, T or B cells, is equipped with a disease sensor, a receptor that recognizes and binds to disease antigens. Human beings are capable of making an astronomical number of receptors by shuffling and recombining a small group of genes. For the past ten years, we have been developing high throughput sequencing methods to study immune repertoires. We have studied more than 40,000 normal and patient samples and our database accumulated several billions of receptor sequences.