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Thyroid Stimulating Hormone

Get a free nursing lab values cheat sheet at NURSING.com/63labs (http://nursing.com/63labs)   Objective: Determine the significance and clinical use of  Thyroid Stimulating Hormone in clinical practice   Lab Test Name: Thyroid Stimulating Hormone   Description: Thyroid Stimulating Hormone (TSH) is released from the anterior pituitary in response to low levels of thyroid hormone.  TSH stimulates the thyroid gland to release thyroid hormones • Triiodothyronine (T3)  • Thyroxine (T4) • T3 and T4 have an inverse relationship with TSH   Indications: Aids to diagnose: • Hyperthyroidism • Hypothyroidism • Anterior pituitary function Monitor:  • Thyroid replacement therapy   Normal Therapeutic Values: Normal –  2-10 mU/L Collection: •  Plasma separator tube   What would cause increased levels? TSH levels increase in the following conditions: • Hypothyroidism • Thyroidectomy • Thyroid dysfunction • Thyroiditis • Thyroid Agenesis • Large doses of iodine • Pituitary TSH-secreting tumor   What would cause decreased levels? Recall the inverse relationship between TSH and T3/T4 labs, and how the negative feedback loop works with these hormones. TSH levels decrease in the following conditions: • Anterior pituitary hypofunction- If the pituitary isn’t secreting TSH, the level will be low. • Hyperthyroidism- If there is a large amount of thyroid hormone circulating, the feedback system relays the info upstream and less TSH is released.