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𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩⚕ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊 📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 : / clinical.learning 2. Antimetabolites: Purine Analogs: Pharmacology Video Lectures ----------------------------------------------------------------------------------------------------------- Purine analogs are a class of antimetabolite drugs that interfere with purine metabolism, essential for DNA and RNA synthesis, and are widely used in the treatment of cancer and autoimmune diseases 🧬⚡. Mercaptopurine (6-MP) and thioguanine (6-TG) are classic purine analogs, acting by mimicking hypoxanthine and guanine, which are converted into false nucleotides that are incorporated into DNA and RNA, disrupting their replication and leading to cell cycle arrest and apoptosis of rapidly dividing cells 🩸💥. Fludarabine, another purine analog, is used in chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma, where it gets phosphorylated to its active form and inhibits DNA polymerase and rib ribonucleotide reductase, preventing DNA synthesis and repair 🧬🔬. These agents are commonly used in combination chemotherapy regimens, as they potentiate the effects of other anticancer drugs, like alkylating agents and antimetabolites 💊💡. However, they can lead to severe myelosuppression, hepatotoxicity, and GI disturbances, and require careful dosing and monitoring of blood counts 🩸⚠️. In addition, thiopurine methyltransferase (TPMT) testing is important to avoid toxicity, as low TPMT activity can result in life-threatening bone marrow suppression in patients on 6-MP or 6-TG 🚑💉. Purine analogs are indispensable in the treatment of hematologic malignancies, solid tumors, and certain autoimmune diseases, highlighting their importance in modern oncology and immunology 🌍❤️. #PurineAnalogs #6Mercaptopurine #Fludarabine #Thioguanine #Antimetabolites #CancerTherapy #Chemotherapy #DNAReplication #ImmunosuppressiveTherapy #MedicalScience #Pharmacology #USMLE #NEETPG #Oncology #Hematology #SaveLives #RationalDrugUse 💊🩸🧬💉🏥