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Michael Brown, MD, delivered the 2016 Lasker/APSA Award Lecture at the 2016 Annual Meeting of the American Physician Scientists Association (APSA) in Chicago, IL. Dr. Brown and his partner Joseph Goldstein, MD made fundamental discoveries related to the biochemistry and physiology of blood cholesterol, work which led to the 1985 Nobel Prize in Physiology or Medicine. His work led directly to the development of statin drugs, today used by millions to reduce the risk of cardiovascular disease. Dr. Brown's lecture, "Why Prizes?", explored the importance of scientific prizes in modern biomedical research and detailed the remarkable decade of "Nobelity" at the National Institutes of Health (NIH), a nine-year period during which the cohort of physician-scientists at the NIH produced nine Nobel Laureates. APSA is grateful to the Albert and Mary Lasker Foundation for making this award lecture possible. To learn more about the Lasker Foundation, visit http://www.laskerfoundation.org/