NEW STUDY: Why YOU MUST combine a Senolytic with your NAD Booster скачать в хорошем качестве

NEW STUDY: Why YOU MUST combine a Senolytic with your NAD Booster

A recent study led by Dr. Judith Campisi and Dr. Eric Verdin at the Buck Institute for Research on Aging in California has found a direct link between zombie cells, CD38, Senolytics and keeping our NAD levels high. I hope you enjoy my content and find it interesting or informative, hopefully both; if so please consider supporting the channel by signing up to: Patreon: https://bit.ly/3hhfjl5 Subscribestar: https://bit.ly/3psYo23 10% Discount Code – MYNMN NMN 60 Capsules: https://bit.ly/3cup3FE Trans-resveratrol 60 Capsules: https://bit.ly/2WOdIJL  TMG 60 Capsules: https://bit.ly/3enP36z  Berberine 366 Capsules: https://bit.ly/2SZFEcC  NMN & Resveratrol Capsules: https://bit.ly/2Lqmyba Hyaluronic Acid 60 Capsules: https://bit.ly/33dUiCP Fisetin 60 Capsules: https://bit.ly/32AiywX Vitamin D3, K2 & Magnesium 60 Capsules: https://bit.ly/2FsAgLt Quercetin 60 Capsules: https://bit.ly/3kKVJyM Biological Age Test Kit: https://bit.ly/3b1XinI 10% Discount Code – MYNMN https://singularityhub.com/2020/11/24... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.thelancet.com/journals/eb... https://www.nature.com/articles/s4225... https://www.nature.com/articles/s4159... https://www.nature.com/articles/s4159... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.nature.com/articles/s4158... https://www.healtheuropa.eu/senolytic... In the article Shelly references the parable of the blind men and the elephant and likens it to Longevity • For those unfamiliar with the parable, in essence blind men who don’t know what an elephant is are asked to touch a different body part and then conceptualize what the animal is like, because of their limited experience and specific area of touch, each man has vastly different conclusion and they all believe that they’re description is correct. • She says that aging, thanks to its complexity, is the bio-medical equivalent of the elephant. In that researchers have focused on either one or another “hallmark” of aging, with some success, but not a number together  Joining the Dots • For example, past research has shown us that energy production in our cells can become erratic and non-functional as we age. Cells programmed for apoptosis don’t die, but instead become zombie-like “senescent cells,” • A "senescent cell" is a cell in our body whose telomeres have reached their "Hayflick Limit" i.e. its telomeres have become so short that the cell cannot divide anymore • It is not a healthy cell anymore, it’s not exactly dead, but it is programmed for death, this cell death is called apoptosis, the Greek for self-eating, if it doesn’t die it starts to produce chemicals that increase inflammation and damage our DNA • The key is to find out how other hallmarks of aging, such as lower NAD, inflammation and shortening telomeres interact with zombie cells, so we can see the whole picture. A new study published in Nature Metabolism has starting to connect the dots. A study, in mice, linked-up three promising anti-aging pathways • Attacking senescent cells • Addressing inflammation • Tackling unreliable energy production in cells All three elements point to one key factor that drives aging. • As we age our cells start losing NAD and with reduction our mitochondria become less able to produce the energy we need, which in turn flips normal cellular function into dysfunction. At present this hypothesis has only been prove in mice. • One dysfunctional element is that cells programmed to die through apoptosis don’t die, are not consumed by the body as extra fuel, but instead hang-around as senescent or zombie cells • These zombie cells then turn to the dark side, and start to leak an inflammatory cesspool of molecules called Senescence Associated Secretory Phenotypes (SASP) that “spread” harm and injury to adjacent healthy cells So, if zombie cells are the directors, then getting rid of them should reduce CD38 and in turn, preserve our NAD; well that’s the theory • The team injected the mice with a drug that damaged their DNA. This mimicked aging, in the sense that it increased zombie cells and CD38 • Result, killing the zombie cells lowered CD38 levels, which in turn preserved NAD Senolytics are a class of drugs that selectively clear senescent cells. o Quercetin (a plant Flavonol available in supplement form) o Fisetin (a dietary Flavonoid available in supplement form) #senolytics #livelonger #DavidSinclair DISCLAIMER: This video and description contains a discount code, which means that if you use the code, I will receive a small commission.  Also, although they don’t actually pay me, DoNotAge.org has sent me free products by way of sponsorship.