Autonomic Pharmacology | Muscarinic Antagonists скачать в хорошем качестве

Autonomic Pharmacology | Muscarinic Antagonists

Official Ninja Nerd Website: https://ninjanerd.org You can find the NOTES and ILLUSTRATIONS for this lecture on our website at: https://www.ninjanerd.org/lecture/aut... Ninja Nerds! In this high-yield pharmacology lecture, Professor Zach Murphy delivers a comprehensive breakdown of Muscarinic Antagonists, exploring their mechanisms of action, receptor selectivity, clinical uses, and adverse effects. This lecture is designed to strengthen your understanding of how these agents work within the autonomic nervous system to block parasympathetic activity. We begin with a brief review of the parasympathetic nervous system, focusing on muscarinic receptor subtypes (M1–M5) and their distribution throughout the body. From there, we dive into the major muscarinic antagonists, including: • Atropine • Scopolamine • Ipratropium & Tiotropium • Oxybutynin, Tolterodine, Darifenacin • Benztropine & Trihexyphenidyl Each agent is discussed in detail, highlighting: • Mechanism of action: Competitive inhibition at muscarinic receptors • Receptor specificity: Organ system effects (CNS, lungs, heart, bladder, eyes, GI tract) • Clinical applications: Including bradycardia, COPD, motion sickness, overactive bladder, and Parkinson's disease • Adverse effects: Dry mouth, constipation, blurred vision, urinary retention, confusion, and risk in elderly patients Enjoy the lecture and support us below! Table of Contents: 0:00 Lab 0:07 Muscarinic Antagonists Introduction 0:37 Cholinergic Physiology 11:19 Types of Muscarinic Antagonists: Tertiary vs. Quaternary Amines 32:20 Anticholinergic Toxicity 39:49 Muscarinic Antagonists Practice Problems 43:44 Comment, Like, SUBSCRIBE! Pharmacology Source: Whalen, Karen. Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series). Wolters Kluwer Health. Kindle Edition. 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media   / ninjanerdlectures     / ninjanerdlectures     / ninjanerdlectures   https://x.com/ninjanerdsci/   / ninja-nerd   💬 Join Our Community Discord:   / discord   #ninjanerd #pharmacology #medicine