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Editor's note: With the continuous understanding of virology, cell biology and host immunity of chronic hepatitis B virus (HBV) infection, the field of hepatitis B is developing rapidly. However, judging from the current situation, only close cooperation among different research fields can achieve the functional cure of chronic HBV infection. To this end, the International League Against HBV (ICE-HBV) and the European Association for the Study of the Liver (EASL) jointly organized the symposium "Understanding Immunology and Virlogic Reactions in the Liver to Cure HBV Infections" during the 56th EASL Annual Meeting in 2021, aiming to share the latest progress and provide more opportunities for researchers committed to developing methods to cure persistent HBV infection. Hepatology Digest has the honour to invite the moderator, one of the sponsors of ICE-HBV, a leading expert in the field of clinical viral hepatitis and antiviral treatment, Professor Fabien Zoulim of the University of Lyon, France, to look forward to the next 10 years of HBV cure.