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In this conversation, I discuss anabolic resistance in ageing muscle, why masters athletes look different to their untrained peers, and how inactivity, disease and poor nutrition drive secondary sarcopenia. We explore the continuum of anabolic resistance, what this means for protein intake and the leucine threshold, and why simply eating more protein will not reverse it. We examine how resistance training influences chronic inflammation, hormones and satellite cell activity, with implications for type II fibres, strength and function. Crucially, we consider what someone in their 50s, 60s and beyond can expect if they start now, drawing on meta-analyses in adults over 75 and a landmark study in 90-year-olds that highlights how quickly meaningful gains can occur. Stream the full episode on YouTube: • Muscle, Aging & Longevity: What the Scienc... Or listen on your favourite podcasting platform: https://theproof.com/building-muscle-... Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit https://theproof.com/friends/. • The Proof with Simon Hill - https://theproof.com/podcast/ • Book: The Proof is in the Plants - https://theproof.com/book/ • Apple Podcast - https://podcasts.apple.com/gb/podcast... • Spotify - https://open.spotify.com/show/7bAIJCV... • Instagram - / theproof • Twitter - / theproof • Facebook - / theproofwithsimonhill • Plant-Based Ferments Guide - https://theproof.com/ferments/ • Two-week meal plan - https://theproof.com/mealplan/ • Plant Performance - https://theproof.com/plant-performance/ • Use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends.