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From Europe to North America and now Asia, Wilhelm Foundation's the Undiagnosed Hackathon has grown into a powerful global collaboration to solve some of medicine’s most complex mysteries. What began as an experimental model in collaborative diagnostics now brings together clinicians, geneticists, bioinformaticians, researchers, data scientists, and families with one shared mission: to find new ways to solve undiagnosed diseases and bring answers to children and adults still living without a diagnosis. During each 48-hour Hackathon, global experts work intensively on complex cases that remain unsolved despite years of medical investigations. By combining advanced genomic technologies, data analysis, and clinical expertise, teams search for the one thing families have been waiting for—a diagnosis. Every diagnosis found brings clarity, direction for care, and renewed hope. At the same time, each discovery advances science and helps more people living with undiagnosed diseases worldwide. Because solving the unsolved requires global collaboration—and together, we can push the frontiers of medicine forward.