Krebs Cycle step by step |Citric acid Cycle or TCA| скачать в хорошем качестве

Krebs Cycle step by step |Citric acid Cycle or TCA|

After pyruvate is oxidized, the citric acid cycle completes the energy-yielding oxidation of organic molecules Glycolysis releases less than a quarter of the chemical energy in glucose that can be harvested by cells; most of the energy remains stockpiled in the two molecules of pyruvate. When O2 is present, the pyruvate in eukaryotic cells enters a mitochondrion, where the oxidation of glucose is completed. Upon entering the mitochondrion via active transport, pyruvate is first converted to a compound called acetyl coenzyme A, or acetyl CoA. This step, linking glycolysis and the citric acid cycle, The citric acid cycle functions as a metabolic furnace that oxidizes organic fuel derived from pyruvate. Pyruvate is broken down to three CO2 molecules, including the molecule of CO2 released during the conversion of pyruvate to acetyl CoA. The cycle generates 1 ATP per turn by substrate-level phosphorylation, but most of the chemical energy is transferred to NAD+ and a related electron carrier, the coenzyme FAD (flavin adenine dinucleotide, derived from riboflavin, a B vitamin), during the redox reactions. The reduced coenzymes, NADH and FADH2, shuttle their cargo of high-energy electrons into the electron transport chain. The citric acid cycle is also called the tricarboxylic acid cycle or the Krebs cycle, the latter honoring Hans Krebs, the German- British scientist who was largely responsible for working out the pathway in the 1930s. #KrebsCycleSteps