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Programmable on-chip DNA compartments as Artificial Cells

Programmable on-chip DNA compartments as Artificial Cells Air date: Wednesday, November 19, 2014, 3:00:00 PM Category: WALS - Wednesday Afternoon Lectures Runtime: 00:49:11 Description: Wednesday Afternoon Lecture Series For his WALS lecture, Dr. Bar-Ziv will discuss the assembly of two-dimensional DNA compartments that are fabricated in silicon. These artificial cells are capable of metabolism, programmable protein synthesis, and communication. Metabolism is maintained by continuous diffusion of nutrients and products through a thin capillary, connecting protein synthesis in the DNA compartment with the environment. The Bar-Ziv laboratory programmed protein-expression cycles, autoregulated protein levels, and a signaling-expression gradient, equivalent to a morphogen, in an array of interconnected compartments at the scale of an embryo. Gene expression in the DNA compartment reveals a rich, dynamic system that is controlled by geometry, offering a means for studying biological networks outside a living cell. For more information go to http://wals.od.nih.gov Author: Roy Bar-Ziv, Ph.D., Associate Professor, Weizmann Institute of Science, Israel and Radcliffe Institute for Advanced Study, Harvard University Permanent link: http://videocast.nih.gov/launch.asp?1...