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Antimicrobial resistance (AMR) is one of the most serious health threats for both animals and humans. The Agricultural Research Service (ARS) within the United States Department of Agriculture (USDA) is mandated to solve agricultural issues of high national priority and AMR is a national and international priority. As an agricultural research organization, ARS is uniquely positioned to identify AMR solutions to promote animal, plant, environmental and public health (collectively known as One Health) while sustaining agriculture. ARS scientific experts across the One Health spectrum (animal, plant, environment and food safety) collaborated to identify ARS priority research needs that will advance the science and identify solutions. In a 5-part series, the AMR Research Webinars highlighted research with U.S. and international partners/stakeholders that ARS and others are performing to address AMR and alternative to antibiotics in agriculture. This session will focus on the priority topic of Risk. Speakers will discuss the development of risk tools and models to assess drivers of AMR across agricultural settings and the development of predictive analyses.