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This video is about OB Paper: ALPS trial. Gyamfi-Bannerman et al., (2016): https://www.nejm.org/doi/full/10.1056... ALPS trial on preterm steroids is a clinical trial aimed at determining the efficacy of administering antenatal steroids to women with late preterm pregnancies. The trial is being conducted by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) in collaboration with several other research institutions. Late preterm pregnancies are those that occur between 34 and 36 weeks of gestation, and babies born during this time period are at an increased risk of complications such as respiratory distress syndrome, jaundice, and hypoglycemia. Antenatal steroids have been shown to reduce the risk of these complications in babies born before 34 weeks of gestation, but their efficacy in babies born between 34 and 36 weeks has not been well established. The OBGYN ALPS trial aims to address this gap in knowledge by enrolling over 5,000 women with late preterm pregnancies and randomly assigning them to receive either antenatal steroids or a placebo. The trial will assess the outcomes of the babies born to these women, including the incidence of respiratory distress syndrome, as well as the maternal outcomes such as the need for cesarean delivery. The results of this trial will help inform clinical practice and improve the care of late preterm babies and their mothers. The conclusion: Administration of betamethasone to women at risk for late preterm delivery significantly reduced the rate of neonatal respiratory complications. (Funded by the National Heart, Lung, and Blood Institute and the Eunice Kennedy Shriver National Institute of Child Health and Human Development; ClinicalTrials.gov number, especially has some good data. 20% reduction even when only 60% of their target arm received BMTZ. You heard that right - put down your coffee and learn yourself about the ALPS trial. Keywords for the algorithm: steroids, preterm, delivery, obstetrics, betamethasone, dexamethasone, respiratory, lung, maturity, hypoglycemia, ards, ttn, nec, nicu, supplemental oxygen, intubation, fetal demise, pneumonia, cesarean section, c section, apnea, chorio, endometritis, hyperbilirubinemia, surfactant, bronchopulmonary dysplasia, bpd, cpap, ecmo, pulmonary