New Anti Crispr Just Dropped ｜Biochem Bits скачать в хорошем качестве

New Anti Crispr Just Dropped ｜Biochem Bits

Support the channel by signing up for a free 30-day trial of Brilliant at https://brilliant.org/Clockwork/ and get 20% off an annual premium subscription. 📰 There are so many new incredible discoveries hitting the newswire every week. I want to start exploring a few of them with y'all each month. Today, let's check out a newly discovered potential Anti CRISPR protein that blocks the efficacy of Cas13b -- an RNA cutting member of the broad CRISPR family. 🔪Then, we'll check out how three separate rock-star teams managed to develop an in vitro model that reconstitutes SPO11's DNA-cutting ability. Wow, I guess this is just the 'DNA Cutting Special` here at Clockwork. 🤝 This channel is created with the support of all our patrons on Patreon:   / clockworkshow   💌 One great way you can also help out the channel is by joining our newsletter: https://bit.ly/watchclockwork 💻 Rendered using @BradyJohnston 's open-source Molecular Nodes Add-on for Blender: https://extensions.blender.org/add-on... 📚Read the papers I covered here: ⚡ New CRISPR-Cas13b Inhibitor: AcrVIB1 inhibits CRISPR-Cas13b immunity by promoting unproductive crRNA binding accessible to RNase attack Wandera, Katharina G. et al. Molecular Cell, Volume 85, Issue 6, 1162 - 1175.e7 https://doi.org/10.1016/j.molcel.2025... 🗡SPO11 Goes In Vitro: Paper from UC Louvain: SPO11 dimers are sufficient to catalyse DNA double-strand breaks in vitro Oger, C., Claeys Bouuaert, C. SPO11 dimers are sufficient to catalyse DNA double-strand breaks in vitro. Nature 639, 792–799 (2025). https://doi.org/10.1038/s41586-024-08... Paper from Sloan Kettering: Reconstitution of SPO11-dependent double-strand break formation Zheng, Z., Zheng, L., Arter, M. et al. Reconstitution of SPO11-dependent double-strand break formation. Nature 639, 784–791 (2025). https://doi.org/10.1038/s41586-025-08... Paper from the Shanghai Institute of Biochemistry and Cell Biology: In vitro reconstitution of meiotic DNA double-strand-break formation Tang, X., Hu, Z., Ding, J. et al. In vitro reconstitution of meiotic DNA double-strand-break formation. Nature 639, 800–807 (2025). https://doi.org/10.1038/s41586-024-08... ❗ Moving forward, I'll be publishing just ONE fresh paper breakdown at a time. This video really should have been broken up into two separate parts. Let me know if y'all like this format or if we should keep things more in-depth here. Join this channel to get access to perks:    / @clockworkbio