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This webinar took place on June 16, 2025. This webinar explores two understudied conditions: Orgasmic Anhedonia, where individuals experience orgasm without pleasure, and Post-Orgasmic Illness Syndrome (POIS), characterized by debilitating symptoms following orgasm. Both pose significant challenges for clinicians and researchers in sexual medicine, as they can profoundly impact quality of life and relationship satisfaction. Experts Irwin Goldstein and Jim Pfaus will examine the neurobiological and physiological substrates of orgasmic dysfunction. The presentations will provide an in-depth discussion of the clinical manifestations, diagnostic challenges, and potential therapeutic approaches, highlighting the latest scientific findings and future research directions. By exploring the complexities of Orgasmic Anhedonia and POIS in both men and women, this webinar aims to advance our understanding of these conditions and promote the development of effective treatments. Program Opening by Moderator: Linda Weiner Presentation 1: Orgasmic Anhedonia - Irwin Goldstein Presentation 2: Post-Orgasmic Illness Syndrome - Jim Pfaus Discussion