Suprachoroidal Route of Drug Administration ; injecting medications into the suprachoroidal space скачать в хорошем качестве

Suprachoroidal Route of Drug Administration ; injecting medications into the suprachoroidal space

The suprachoroidal route of drug administration is an advanced ocular drug delivery method that targets the suprachoroidal space (SCS)—the area between the sclera and choroid. This technique is particularly useful for treating posterior segment diseases such as macular edema, diabetic retinopathy, and age-related macular degeneration (AMD)2. Key Features Minimally invasive: Uses a microneedle to inject medication into the suprachoroidal space. Targeted drug delivery: Enhances drug penetration to the retina and choroid. Reduced systemic exposure: Limits unwanted side effects compared to systemic administration. Advantages Higher drug concentration: Studies show up to 12-fold higher drug delivery compared to intravitreal injections. Lower risk of complications: Avoids damage to the optic nerve and anterior segment. Potential for sustained release: Some formulations allow long-term drug delivery. Challenges Complex anatomical barriers: The blood-retinal barrier may limit drug penetration. Limited clinical adoption: While promising, this method is still under investigation. Risk of complications: Improper injection may cause ocular inflammation or retinal damage. The FDA-approved drug for suprachoroidal injection is Triamcinolone Acetonide (Xipere), used for macular edema associated with non-infectious uveitis #drugadministration