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Everything you need to know about E2, bimolecular elimination: mechanism, Zaitsev's Rule for determining major products, when Zaitsev's Rule FAILS, and tricky cases like cyclic structures and choosing the major product between a pair of cis/trans isomers. (Zaitsev's Rule is also called Zaytsev's Rule, Saytzeff's Rule, or Saytzev's Rule.) Need a refresher? • Newman Projections of Butane • Cyclohexane: Conformations and Ring Inver... Playlists to ACE Chemistry: • Organic Chemistry Reaction Mechanisms • Organic Chemistry Essentials | Reactions, ... • How Scientists Figured Out Atomic Structure • General Chemistry Basics That Matter • Significant Figures • The Benzene Puzzle & Aromaticity • Lab Techniques & Instrumentation • Fun Stuff 🧪Early access to videos & more through Patreon! / chemistryinanutshell 🔬As an Amazon Affiliate, I earn from qualifying purchases at no extra cost to you. Start your shopping here: https://amzn.to/3IXuAcS 0:00 Bimolecular Elimination Reactions 0:25 E2 Overall Equation 1:45 E2 Generic Pattern 4:29 Symmetrical (Easier) Example 6:42 Zaitsev's Rule Example 9:53 4 Exceptions to Zaitsev's Rule 10:16 1 Conjugated Double Bond Systems 11:35 2 Bulky Bases 12:17 3 Leaving Group is too Basic 13:31 Fluorides... 13:54 4 Anti- & Syn- 16:42 Cyclic Systems 20:51 cis- vs trans- Major & Minor Products 21:31 Newman Projection Leading to Major Product 22:28 Newman Projection Leading to Minor Product 22:58 Why these lead to major vs minor 24:23 Newman Projections You Can Ignore 25:26 & when you can't ignore Citations: Paula Yurkanis Bruice, "Organic Chemistry" 8th ed Chapter 9, base reactivity data from table 9.5 https://openstax.org/details/books/or... https://openstax.org/details/books/ch... Music: • Electron Clouds with a Chance of Swing