Biocatalysis: Scaling Lab Concepts to Industrial KPIs скачать в хорошем качестве

Biocatalysis: Scaling Lab Concepts to Industrial KPIs

This Episode outlines a professional engineering framework for transitioning biocatalytic innovations from the laboratory to large-scale industrial production. It emphasizes a systematic route-selection process, requiring a strategic choice between cell-free and whole-cell methods based on factors like toxicity, cofactor regeneration, and purification needs. By establishing rigorous Key Performance Indicators (KPIs), such as space-time yield and enzyme turnover numbers, the framework ensures that biological processes meet the economic and regulatory standards of the pharma, feed, and energy sectors. The sources illustrate how integrating techno-economic assessments and life-cycle analyses allows manufacturers to replace traditional chemical synthesis with more sustainable, enzymatic alternatives. Ultimately, the guide asserts that commercial success depends on identifying and controlling operational failure modes early in the design phase. #Bioprocess #ScaleUp and #TechTransfer, #Industrial #Microbiology, #MetabolicEngineering and #SystemsBiology, #Bioprocessing, #MicrobialFermentation, #Bio-manufacturing, #Industrial #Biotechnology, #Fermentation Engineering, #ProcessDevelopment, #Microbiology, #Biochemistry #Biochemical Engineering, #Applied #MicrobialPhysiology, #Microbial #ProcessEngineering, #Upstream #BioprocessDevelopment, #Downstream Processing and #Purification, #CellCulture and #MicrobialSystems Engineering, #Bioreaction #Enzymes #Biocatalyst ------------------------------------------------------------- Timestamp Timestamp Problem Addressed 02:44 – 03:35 Route Selection Strategy 03:43 – 04:29 Cell Membrane Bottlenecks 08:02 – 09:00 Enzyme Cost & Co-factors 10:39 – 11:42 Downstream Processing (DSP) 14:42 – 16:10 Bioreactor Physics Limits 20:51 – 22:17 Enzyme Stability in Feed 23:26 – 24:05 Scale-Up Economics 28:53 – 29:36 Continuous Manufacturing