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Download free rotation guides: https://info.sketchy.com/guide/all-cl... Download free patient presentation guides: https://info.sketchy.com/guide/all-pa... Try the 7-day free trial to watch this lesson and more from our Pathophysiology https://www.sketchy.com/explore/medic... We’re at the Museum of Myeloid Art, where we’ll break down the key differences between AML (Acute Myeloid Leukemia) and CML (Chronic Myeloid Leukemia). AML is aggressive and rapidly progressive, often a medical emergency, while CML has a more chronic and slower course. We explore how AML is characterized by a high number of immature myeloblasts, whereas CML involves more mature granulocyte forms. Both leukemias typically present in patients around 60 years old, with distinct genetic markers: AML with the PML-RARA translocation and CML with the BCR-ABL fusion protein. We also discuss the diagnostic criteria for AML, including the presence of 20% blasts in the bone marrow, and the unique progression of CML, which can accelerate into a blast phase resembling AML. — Sketchy is the #1 visual learning platform, created by the team behind SketchyMicro and SketchyPharm. We take what you need to know for your courses and exams and turn it into unforgettable, story-driven lessons using the proven ‘method of loci’ memorization technique. The Sketchy Method accelerates learning, boosts retention, and improves test scores—(trust us, we’re doctors). But mastering medicine isn’t just about memorization—it’s about applying knowledge. That’s why we built Sketchy Cases, our interactive clinical reasoning tool. Cases put you in real-world scenarios where you’ll build and defend differentials, take patient histories, interpret labs, and get feedback just like you would in rotations. Whether you’re preparing for clinicals, OSCEs, or board exams, Sketchy Cases gives you the practice you need to sharpen your diagnostic skills and grow confident in decision-making. Explore Sketchy Cases: https://www.sketchy.com/explore/medic... From foundational science to clinical reasoning, Sketchy has comprehensive programs to help you study smarter and score higher on the USMLE, MCAT, PANCE, and NP boards. Learn more about: Sketchy MCAT: https://www.sketchy.com/explore/mcat?... Sketchy Med: https://www.sketchy.com/explore/medic... Sketchy NP: https://www.sketchy.com/explore/np?ut... Sketchy PA: https://www.sketchy.com/explore/pa?ut... --- Medical disclaimer: Sketchy Group LLC does not provide medical advice. Sketchy Group LLC and the content available on Sketchy Group’s properties (Sketchy.com, YouTube, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.