Isotope Day 2023- Mass Spectrometry with Jurre Kamphorst, PhD скачать в хорошем качестве

Isotope Day 2023- Mass Spectrometry with Jurre Kamphorst, PhD

"Highly Standardized Metabolic Analysis of Clinical Samples Using Triple Quadrupole Mass Spectrometry" Jurre Kamphorst, VP of Mass Spec Technology & Biomarkers at Olaris, discusses recent developments in clinical metabolomics using targeted MS methodologies. He shares how Olaris combines metabolomics and machine learning to revolutionize disease diagnosis and treatment.Kamphorst highlights the advantages of triple quadrupole mass spectrometry in diagnostics and clinical metabolomics, including data quality, targeted analysis, and the potential for standardized approaches across labs. He explains how Olaris has developed a metabolite panel of 224 polar metabolites measurable in a single run.The talk focuses on the use of 13C-internal standards to improve data quality and normalization. Kamphorst presents experiments demonstrating the effectiveness of uniformly labeled 13C metabolite yeast extracts in enhancing linearity of response and enabling better normalization procedures.He concludes by emphasizing the shift in bioanalytical emphasis from broad coverage in preclinical metabolomics to high accuracy and reproducibility in clinical translation, underscoring the value of targeted MS and platforms combining multiple technologies like NMR and LC-MS. Visit our website: https://isotope.com/