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Millions of people and their families are affected by diseases – Alzheimer’s, Parkinson’s – caused primarily by our own proteins going rogue. Ongoing research is revealing new approaches for diagnosis and treatment. Byron Caughey, PhD, is a biochemist at Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases. After graduate work at the Universities of Wisconsin-Madison and London, and post-doctoral work at Duke University, he moved to RML in Hamilton in 1986. His lab’s research has focused mostly on neurodegenerative diseases caused by protein misfolding, including Alzheimer’s, Parkinson’s, and prion diseases. Their recent discoveries range from solving the first structures of highly infectious and deadly prion pathogens to developing much-needed ultra-sensitive and accurate diagnostic tests for a variety of protein misfolding diseases. He has published over 250 scientific papers and served as an editor of several scientific journals. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx