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Steven J. Frank, MD, FACR, FABS, FASTRO, Professor of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, discusses advancements in MRI-assisted radiosurgery (MARS) for prostate cancer. In this 17-minute presentation, Dr. Frank focuses on its application in high-risk and recurrent cases. Dr. Frank highlights the significance of MRI in improving post-implant assessments for brachytherapy, which addresses the limitations of traditional ultrasound and CT imaging. The development of an MRI-positive contrast marker that enhances the visualization of implanted seeds and ensures precise quality control. This also reduces complications such as strictures and fistulas while preserving continence and erectile function. Dr. Frank presents data from a 15,000-patient series that supports a PSA threshold of 0.2 ng/mL at four years as a biochemical definition of cure. Early outcomes using MRI-integrated proton therapy and low-dose-rate brachytherapy boost, demonstrate its effectiveness in high-risk patients. The use of hydrogel spacers and fiducials further optimizes implant accuracy and minimizes toxicity. Dr. Frank emphasizes that MRI should be utilized at every stage of the treatment process to enhance outcomes and reduce complications. Data supports MARS as a safe and effective option for managing complex prostate cancer cases. Don't forget to join the GRU Community: https://grandroundsinurology.com/regi... Follow us on Twitter/X: https://x.com/GRUrology And like and subscribe to us here on YouTube!