Platelets in Physiology: Structure, Formation, Mechanism of Action and Vital Functions скачать в хорошем качестве

Platelets in Physiology: Structure, Formation, Mechanism of Action and Vital Functions

Platelets, also known as thrombocytes, are small, anucleate cell fragments derived from megakaryocytes in the bone marrow. Their production is regulated mainly by thrombopoietin. In normal physiology, platelet count ranges from 150,000–400,000 per microliter of blood. Platelets play a crucial role in hemostasis. When a blood vessel is injured, they adhere to exposed collagen through von Willebrand factor, become activated, and release chemical mediators like ADP, thromboxane A₂, and serotonin. This leads to platelet aggregation and formation of a temporary platelet plug. They also provide a phospholipid surface for activation of clotting factors, promoting coagulation and stable fibrin clot formation. In addition to hemostasis, platelets are involved in wound healing, inflammation, immune response, and maintenance of vascular integrity. Disorders of platelets can result in bleeding tendencies or thrombotic conditions. #Platelets #Thrombocytes #Hemostasis #BloodClotting #Megakaryocytes #Thrombopoietin #VonWillebrandFactor #Physiology #Coagulation #WoundHealing