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Listen to leading neuroscientists discuss how they are using artificial intelligence to map the brain in this latest Lab Notes podcast hosted by the Allen Institute. How does the brain work? Scientists are closer to answering this enigma with the largest wiring diagram and functional map of a mammalian brain to date. In April 2025, the Allen Institute, as part of a global team, unveiled what was once thought impossible: a high-resolution functional map of a cubic millimeter of brain, revealing both form and function. In this Lab Notes episode, the Allen Institute’s Clay Reid, M.D., Ph.D., Nuno da Costa, Ph.D., and Forrest Colman, Ph.D., and scientific collaborator, Andreas Tolias, Ph.D., explain how they created a “digital twin” of a portion of the mouse brain the size of a grain of sand and how they used artificial intelligence to digitally reconstruct a labyrinth of brain cells and wiring from 95 million high resolution images – stitching together the elaborate architecture that underpins the “language of the brain.“ Lab Notes is revealing the human stories behind the science: https://alleninstitute.org/podcast