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Polypharmacy — the use of multiple medications by a single patient — is one of the most important and complex challenges in modern psychiatry. In this video, I discuss why it’s critical for new providers to carefully assess medication interactions, especially in patients with co-occurring medical or psychiatric conditions. As a PMHNP I’ve seen how easily polypharmacy can spiral into unnecessary side effects, diminished therapeutic response, or even dangerous drug interactions. This video breaks down practical strategies for evaluating medication lists, deprescribing safely, and collaborating across disciplines to ensure patient safety and optimal outcomes. 🧠 In this video, we’ll cover: What defines polypharmacy in psychiatry and medicine Common high-risk combinations to watch for How to perform an effective medication reconciliation The role of communication between prescribers and pharmacists Steps to simplify regimens while maintaining clinical stability Whether you’re a new psychiatric provider, nurse practitioner, or clinician in training, understanding polypharmacy is essential to practicing safe and effective psychiatry. 🔔 Subscribe for more educational videos on psychopharmacology, mental health care, and evidence-based psychiatric practice.