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In this conversation, I speak with Theodore Schwartz, one of the most distinguished neurosurgeons in America. During his career, he has published over 500 scientific papers and is renowned for his contributions to the development of minimally invasive neurosurgical techniques. Dr Schwartz specialises in the treatment of brain tumours as well as other diseases, including epilepsy. Dr Schwartz has provided expert commentary to various media outlets, including ABC, NBC and CBS. Dr Schwartz spent the majority of his career at Weill Cornell Medicine, where he was a Professor of Neurosurgery, Otolaryngology, and Neuroscience. He is now a Professor of Neurosurgery at the Icahn School of Medicine at Mt. Sinai. Dr Schwartz's new book, Grey Matters: A Biography of Brain Surgery, offers profound insights into the life of a neurosurgeon, the historical development of the discipline and the profound complexity of the brain. He excels at making complex ideas accessible, as you will see in this conversation and in the book. Chapters 00:00:00 – Intro 00:01:00 – Harvey Cushing & the birth of modern neurosurgery 00:03:00 – How knowledge is passed on 00:06:00 – Do brains look different? Anatomy vs. functional mapping 00:08:00 – Brain “age” on MRI = subtle atrophy 00:09:00 – Can VR/AI simulate OR pressure? Limits of immersion 00:11:00 – Dexterity vs judgment: what makes a great neurosurgeon 00:13:00 – Performing under pressure: sport analogies (Brady vs Jackson) 00:15:00 – What CTE is (not just NFL): boxing, rugby, sub-concussive hits 00:17:00 – Why some get CTE and others don’t: genetics & testing limits 00:18:00 – What a concussion really is: diffuse axonal injury 00:20:00 – Youth sport: delay contact; skill first, hits later 00:21:00 – Girls, teens & second-impact syndrome (rare but serious) 00:24:00 – The connectome: protecting white-matter highways 00:25:00 – Awake brain surgery: mapping speech in real time 00:28:00 – What we still don’t know: infections, mapping gaps, surprises 00:30:00 – Is progress slowing? New tech creates new “low-hanging fruit” 00:32:00 – Who becomes a neurosurgeon: athletes, nerds, musicians & more 00:34:00 – Neuron loss with age & why “self” isn’t fixed 00:36:00 – Why dualism persists: language, law, religion, culture 00:42:00 – Free will vs determinism & the mystery of consciousness 00:43:00 – Is the brain a computer? Why robots won’t replace surgeons 00:46:00 – Whole-brain emulation: identical for a millisecond 00:47:00 – Neuroplasticity from the OR: hemispherectomy & recovery 00:49:00 – Alzheimer’s: plasticity vs plaques 00:50:00 – Brain–computer interfaces: 1962 to typing by thought 00:51:00 – Reading out vs writing in: why input is harder 00:52:00 – Close & book mention (Gray Matters)