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Multiple Myeloma | Hematology | EXAM CURE MEDICAL Multiple myeloma is one of the most high-yield plasma cell malignancies in clinical exams because it connects bone disease, renal failure, anemia, infection risk, and protein electrophoresis into one classic vignette pattern. In this EXAM CURE MEDICAL lecture, you will master the core pathophysiology and the CRAB framework so you can identify multiple myeloma quickly and choose the correct next investigation or management step. This video is part of the EXAM CURE Hematology and Oncology high-yield series for licensing and residency-entry exams. START HERE Access FREE high-yield updates + sample MCQs: https://www.examcure.com WhatsApp Support: https://wa.me/971552295005 LEARN ABOUT • Plasma cell biology and monoclonal immunoglobulin production • Common isotypes in exams IgG most common IgA second most common • M protein vs Bence Jones protein • Osteoclast activation and osteolytic lesions • Hypercalcemia and renal toxicity mechanisms • The CRAB framework Hypercalcemia Renal failure Anemia Bone lesions • Rouleaux formation and classic lab clues • When to order SPEP, UPEP, skeletal survey • Complication-first management Hydration for hypercalcemia and renal protection Bisphosphonates for skeletal lesions Erythropoietin support for anemia Antibiotics for infections WHY THIS TOPIC IS HIGH-YIELD Most questions test rapid pattern recognition: Older adult with bone pain and fractures Anemia plus renal impairment Elevated total protein or gamma globulins Rouleaux formation M spike on protein electrophoresis PRACTICE WHAT YOU LEARN • Board-style clinical vignettes • Timed mock tests • High-yield crash notes and algorithms FOR EXAM TAKERS Ideal for: • DHA / DOH / MOH / SCFHS • EMREE • SMLE • Internal Medicine, GP, Emergency, and Oncology tracks #MultipleMyeloma #CRAB #BenceJones #Hematology #PlasmaCellDyscrasia #ExamCure #EMREE #SMLE #DHA