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Hepatitis B virus (HBV) and hepatitis C virus (HCV) can become chronic infection, affecting 325 million people worldwide, accounting for 96% of the mortality rate of viral hepatitis. Mother to child transmission is one of the main ways of transmission of these two viruses. Therefore, prevention of mother to child transmission is essential to reduce the burden of chronic viral hepatitis worldwide. Since the treatment of viral hepatitis in pregnancy must take into account the health of the mother and the developing fetus, and the immunosuppressive state, hormone changes and postpartum changes of pregnant women may change the natural process of infection, antiviral treatment in pregnancy is a topic of general concern. At the annual meeting of the American Association for the Study of Liver Diseases (AASLD) in 2022, we invited Professor Carla W. Brady of Duke University School of Medicine to conduct an in-depth interview on this topic. Now we have compiled the content into a text for the readers.