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During this discussion, two leading wildlife epidemiologists will describe how new infectious pathogens are transmitted from one species to another, a process called “spillover,” and what can be done to prevent future pandemics. Are human activities accelerating the emergence of more infectious diseases? What can we learn from areas where spillover is common? In the tropics, for example, a highly populated and biodiverse region, how are land-use changes driving transmission of pathogens from wildlife to people? What other factors influence the likelihood of spillover? An important key to understanding a disease’s origin, researchers say, is focusing on the opportunities for contact between people and the animal hosts of various pathogens. But once an outbreak has occurred, controlling disease spread may require work across several agencies (ministers of agriculture, health, environment, tourism) to quickly prepare diagnostic labs and inform public health outreach, guidance, and regulations.