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References/Resources: / the_crux A deep-dive into the origins of replication. We discuss what makes an origin of replication by looking through the replicon model, replicators, initiators, and ARS in yeast. We also see why origins are important. Specifically, we take an in-depth tour of E. coli origin (oriC), Archaebacteria origins (ORBs), and origins in yeast (ARS) and in other eukaryotes such as mammals. While some origins are defined, we note that eukaryotic replication origins are not defined clearly. Jump to your favorite section: 00:00 Outline 00:38 Intuition about Origin 02:41 Replicon Model 07:02 Bacteria OriC 11:21 DnaA initiator protein 12:42 Archaebacteria ORBs 14:22 Yeast ARS 16:55 Mammalian Origin Must watch playlists: All videos on DNA Replication: • All about DNA Replication! All videos on Transcription: • All about Transcription! All videos on Translation: • All about Translation! Do leave a LIKE if you find this content useful! COMMENT your questions, suggestions, and thoughts :) And I hope you have SUBSCRIBED because there is a lot more coming! :D I appreciate your support.