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Learning Objectives: Brief review of disease and disease mechanism Current management and its efficacy Next generation approach to care Dr. Carla M. Nester, MD, MSA, FASN, is the Jean Robillard MD, Professor of Internal Medicine and Pediatrics, and the Division Director of Pediatric Nephrology at the University of Iowa, Stead Family Children's Hospital in Iowa City, IA. Dr Nester is an Internal Medicine and Pediatric trained (quadruple boarded) NIH-funded, tenured faculty member with a translational research program focusing on rare complement-mediated kidney diseases including aHUS and C3G. She is the primary investigator for the University of Iowa’s C3 Glomerulopathy Natural History Study, which includes one of the largest prospective cohorts of patients with C3 Glomerulopathy available to research. Finally, Dr Nester is a clinical trialist. Her Med-Peds clinical practice has become a hub for bringing the new generation of anticomplement therapeutics to a rare disease population.