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A rough overview is provided of four decades of research into psychedelics in Europe and the US. The progression of research since the late seventies will be discussed, from the resurgence after the ban and further development aided by the founding of the Swiss Physicans Society for Psycholytic therapy (SAEPT) and the European College for the Study of Consciousness (ECSC) in 1985, to the stabilisation of developments marked by the founding of the Multidisciplinary Association for Psychedelic Studies (MAPS) in 1986 and the Heffter Research Institute (HRI) in 1993. From 2010 onwards the scientific climate changed. Substances which were formerly called “dirty drugs” for not being specific to one receptor (system) became interesting again because they may configurate a matrix of brain-functioning helpful for healing. A retrospective view suggests a wave-like pattern of interest in psychedelics. Appropriate recognition of the limits of using these substances in everyday psychiatric/psychotherapeutic practice is discussed. BIOGRAPHY Torsten Passie is currently Visiting Professor at Harvard Medical School (Boston, USA). He studied philosophy, sociology (MA) at Leibniz-University, Hannover and medicine at Hannover Medical School. He worked at the Psychiatric University Clinic in Zürich (Switzerland) and with Professor Hanscarl Leuner (Göttingen), the leading European authority on hallucinogenic drugs. His extensive research at Hannover Medical School covers the psychophysiology of altered states of consciousness and their healing potential, including clinical research with hallucinogenic drugs (cannabis, ketamine, nitrous oxide, MDMA, psilocybin). He is an internationally known expert on altered states of consciousness and the pharmacology of hallucinogenic drugs. ________ To keep yourself up to date with psychedelic research, come celebrate the latest discoveries in our next in-person ICPR conference organized by the OPEN Foundation: https://icpr-conference.com/ See you there!