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Why would a platelet count drop after concentration? In this quick video, Dr. Centeno explains a surprising phenomenon that can occur when platelets aggregate during processing. Using real imaging, Dr. Centeno walks through how platelet clumping can cause automated cell counters to misclassify these aggregates as larger nucleated cells—leading to an artificially low platelet count. This insight is especially important for clinicians working with PRP (platelet-rich plasma) and regenerative therapies. Dr. Centeno is a pioneer in regenerative medicine and practices at the Centeno-Schultz Clinic, where advanced lab techniques are used to accurately process and interpret orthobiologic samples. 🔔 If you find this content helpful, please like, comment, and subscribe to stay informed. / @centenohome To schedule a telemedicine or in-person visit, call +1-303-429-6448 or email us at icabral@centenoschultz.com. Dr. Centeno also answers questions on his Reddit thread at / picl Join him for weekly Facebook Lives at / centenoschultzclinic to learn more. Download Dr Centeno's book on craniocervical instability at https://centenoschultz.com/craniocerv... Join CCI Communities: PICL SubReddit: https://www.reddit.com/r/PICL/?rdt=58942 PICL Facebook Group: / ccjpicl Follow us for updates and news: Website: https://centenoschultz.com/ https://regenexx.com/ Facebook: / centenoschultzclinic Instagram: / centenoschultzclinic LinkedIn: / chris-centeno-m-d-b6838024 Centeno-Schultz Clinic 403 Summit Blvd Suite 201 Broomfield, CO 80021 303-429-6448 Key Timestamps: 00:00 - Introduction – Platelet count drop with concentration 00:06 - Platelet aggregation and clumping 00:18 - How aggregates are misclassified as nucleated cells 00:33 - Why platelet count appears to decrease 00:47 - Summary – Clumping leads to false platelet count drop