WEBINAR: Current Applications and Advances in Tumor Fluorescence 1 скачать в хорошем качестве

WEBINAR: Current Applications and Advances in Tumor Fluorescence 1

Nader Sanai, MD from the Barrow Neurological Institute in Phoenix, AZ discusses applications and advances in tumor fluorescence. With the recent FDA approval of 5-ALA, fluorescence-guided surgery has emerged as a new standard for maximal high-grade glioma resection. Nader Sanai, MD, is the Director of Neurosurgical Oncology at the Barrow Neurological Institute as well as Director of the Ivy Brain Tumor Center. He will discuss advances in the field as they relate to the extension of 5-ALA tumor fluorescence into lower-grade tumors and the recent development of intraoperative technology adjuncts that optimize its utilization in both low- and high-grade gliomas. 0:00 Introduction 2:48 Volumetric Analysis of LGG EOR Role of Extent of Resection in the Long-Term Outcome of Low-Grade Hemispheric Gliomas 3:47 EOR and LGG Overall Survival 4:21 EOR and LGG Transformation 5:54 Biopsy vs. Resection: A Randomized Study 6:27 An Extent of Resection Threshold for GBM 7:22 Minimizing Risk and Maximizing EOR 8:24 Glioma Rates of Gross-Total Resection: Results in the Modern Literature 9:07 5-Aminolevulinic Acid (5-ALA) 11:38 5-ALA: High-Grade Gliomas 13:32 European 5-ALA study Group 16:40 Limitations of Wide-Field Microscopy 17:28 Negative 5-ALA Fluorescence in LGG 20:27 Risk of False-Positive Signal? 20:48 Cellular Specificity of 5-ALA in Human Gliomas Individual PplX(+) cells can be purified and isolated with FACS 22:07 Intraoperative Confocal Microscopy: Cellular Resolution 22:42 5-ALA for Low-Grade Gliomas 23:38 5-ALA Visualization of Low-Grade Gliomas 24:29 Intraoperative Confocal Microscope 26:38 Miniature Dual-Axis Confocal Microscope Multiplexed Imaging for Diverse Panel of Biomarkers