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mTPI a practical approach

mTPI is a study design for phase 1 oncology trials: modified Treatment Probability Interval design. The video teaches what the clinical scientist and medical director need to know in a practical way, and explains the background, puts it in context. The video is part of a teaching series for oncology clinical drug developers. watch the 3+3 design video first    • 3+3 design and more about phase 1   to go deeper in the statistics of mTPI watch these: Optimizing Development in Early Phase: mTPI Case Study, Bayesian Adaptive Dose Finding Trials Neby Bekele 2015    • Optimizing Development in Early Phase: mTP...   Lecture 2 Phase I mTPI design Haito Pan 2022    • Видео   The series is brought to you by Oncology Consulting Wolff LLC, which is solely responsible for its content. https://wolffoncology.com/ . This video was created in on 29th May 2024, there were no conflicts of interest relevant to the topic. We thank Neby Bekele for his kind support. Cancer | Oncology | drug development | clinical development | phase 1 | dose escalation | MTD | DLT | BOIN | CRM | 3+3 | TPI | mTPI . Other videos of the series include: • KM curve – What is that? The basics    • Kaplan Meier Curve - What is that ? the Ba...   • PFS progression free survival explained    • PFS progression free survival explained   • Reading KM curves – Pearls and Details    • Read KM curves - Pearls and Details   • The PFS Paradox – a hidden scandal of Kaplan Meier curves    • The PFS Paradox - a hidden scandal of KM c...   • How to make KM curves, a practical guide. Feb 20 2024    • Видео   • Logrank test    • Logranktest - click by click in SPSS and b...   • Kaplan Meier Exam    • KM exam - challenge your knowledge in clin...   • Response in Cancer Trials – Overview and examples    • Response in cancer trials - overview and e...   • RECIST V1.1 How? Why? Why not    • RECIST V1.1 How? - Why? - Why not? overvie...   • 3+3 design    • 3+3 design and more about phase 1   00:00 - Introduction 00:40 – typical phase 1 study design 02:30 – 3+3 Rules as diagram 04:14 – mTPI table real life example 10:23 – Authors of 2010 paper 11:28 – mTPI high level concept 17:04 – How to go deeper in statistics 18:56 – talk to your statistician 22:16 – Impact do you mTPI design decisions 24:14– summary: upsides and shortcomings 27:05 – disclaimer and COI