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Obliterative and Non-Obliterative restrictive cardiomyopathy (RCM) are two subtypes of RCM, differing in the presence or absence of endomyocardial fibrosis and thrombus: Obliterative RCM: 1. Characterized by: Endomyocardial fibrosis and thrombus Obliteration of the ventricular cavity Often associated with: Hypereosinophilic syndrome Thrombophilia Cancer 2. Echocardiographic features: Reduced ventricular size Increased wall thickness Atrial enlargement Doppler evidence of restrictive physiology 3. Clinical course: Rapid progression to heart failure High risk of thromboembolism Non-Obliterative RCM: 1. Characterized by: Absence of endomyocardial fibrosis and thrombus Normal or near-normal ventricular size Diastolic dysfunction 2. Echocardiographic features: Normal or reduced ventricular size Increased wall thickness Atrial enlargement Doppler evidence of restrictive physiology 3. Clinical course: Gradual progression to heart failure Lower risk of thromboembolism compared to obliterative RCM Key differences: 1. Presence or absence of endomyocardial fibrosis and thrombus 2. Rate of progression to heart failure 3. Risk of thromboembolism Accurate diagnosis and differentiation between these subtypes are crucial for guiding management and predicting outcomes. #Cardiomyopathy