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Scott McNally and IFBB Pro Kuba Cielen break down mitochondrial peptides, retatrutide, and why overusing GLP-1 drugs and peptides can backfire. 0:00 IFBB Pro Kuba Cielen Bodybuilding Update & Off-Season Focus 7:30 When to Adjust Food Intake in a Muscle-Building Off-Season 10:30 Overusing Mitochondrial Peptides & GLP-1 Drugs Like Retatrutide 11:15 Natural Ways to Improve Mitochondrial Health Before Using Drugs 14:00 MOT-C Peptide Timing and Dosing for Bodybuilders 15:30 SS-31 Peptide Dosing, Expectations, and Limitations 18:00 SLU-PP-332 Dosing Limits and Real-World Results 25:10 Blood Work Results After GLP-1 Use — What Changed (and What Didn’t) 32:00 GLP-1 Drugs and Loss of Hunger Tolerance Over Time 33:00 When to Pull Retatrutide Before a Bodybuilding Contest 35:30 Favorite Testosterone Esters for Different Bodybuilding Goals 41:20 Why Estrogen Conversion Changes Cycle to Cycle 43:16 How Much Gear Do You Actually Need to Grow? 45:00 Benefits of Estrogen Control Beyond Symptom Management 49:00 TRT Cycles vs Gym Bro Cycles vs IFBB Pro Cycles 52:20 Best Training Split With Only 1 Hour to Train 55:40 Planning a Second Cycle: 500 Test / 300 Mast 58:30 Using Oral Steroids in the Off-Season 1:03:45 Jordan Peters’ Mindset and Mental Approach to Bodybuilding 1:05:45 Enduring Pain, Side Effects, and Long-Term Tradeoffs 1:09:30 Training to Failure in High-Volume Programs 1:12:45 Increlex Preview and Future Discussion Follow the guys on Instagram : / kuba_sylvester_cielen / scottmcnally1 Follow @KubaSylvesterCielen on Youtube 💪 Support THINK BIG Bodybuilding ❤️ Support the Channel on PatreonHelp us keep the podcast and videos coming. Even $5/month makes a difference.👉 / thinkbigbodybuilding 👕 THINK BIG Bodybuilding Apparel 🔥 Official THINK BIG T-Shirts & MerchTrain. Represent. Support the brand.👉 https://think-big.printify.me/products 🥇 Official Sponsor: TRUE NUTRITION ✅ Custom Supplements Trusted by Bodybuilders• 3rd-party tested• Fully customizable formulas• Used by serious lifters worldwide 💥 Save with code: THINK👉 https://www.truenutrition.com/THINK 🇨🇦 Canadian Viewers — Supplements Made Easy 💊 Huge Deals on Top Brand Supplements in CanadaFast shipping. Trusted retailer.👉 http://www.supplementsource.ca 🔔 Subscribe to THINK BIG Bodybuilding Media 📺 New podcasts, bodybuilding talk, and industry insight👉 / @thinkbigbodybuilding Turn on notifications so you never miss an episode 🎧 Listen to the Podcast (Audio) 🎙 Search “THINK BIG BODYBUILDING” on your favorite app Spotify👉 https://open.spotify.com/show/0RZgpBP... Apple Podcasts👉 https://podcasts.apple.com/us/podcast... 🤝 Help Us Grow 📢 Share this episode with a training partner or friend who loves bodybuilding #bodybuilding #peptides #mitochondria #GLP1 #retatrutide #PEDs #IFBBPro #bodybuildingpodcast #ThinkBigBodybuilding #BloodSweatAndGear #ScottMcNally