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Special thanks to Goldman Philanthropic Partnerships for funding this series. Introduction to Follicular Lymphoma Introduction of Dr. Thomas Witzig from the Mayo Clinic and the topic of discussion: relapsed follicular lymphoma. Brief overview of what follicular lymphoma is and how it typically presents. Key Questions for Diagnosis and Treatment Outlines the important questions a doctor will ask a patient with relapsed follicular lymphoma. Treatment Options for Relapsed Follicular Lymphoma Various treatment approaches available, Dr. Witzig explains that options depend on the patient's prior treatments. CAR-T Cell Therapy CAR-T cell therapy, how a patient's T-cells are genetically modified to specifically target and attack the lymphoma cells, resulting in a high response rate. Bispecific Antibodies Use of bispecific antibodies as another treatment. These antibodies have two "heads", one that attaches to the tumor and another that attaches to a patient's own T-cells, bringing them together to fight the cancer. Zanabrutinib and Other Options The combination of the pill zanabrutinib with obinutuzumab. The R² regimen (rituximab and lenalidomide), highlighting its effectiveness as a second-line treatment. A Personalized Approach to Treatment Personalized treatment plan, doctors will consider the patient's overall health and personal feelings about their disease to create a plan that is right for them. Conclusion and Acknowledgments The video concludes with a thank you to the patients, the Mayo Clinic team, and the Goldman Philanthropic Partnerships for their support in creating the video series. Quick Timestamps: 00:00 - Introduction to Follicular Lymphoma 00:40 - Key Questions for Relapsed Lymphoma 02:08 - Treatment Options 02:43 - CAR-T Cell Therapy 03:20 - Bispecific Antibodies 04:00 - Zanabrutinib and Other Options 04:57 - A Personalized Treatment Plan 05:44 - Conclusion and Acknowledgments Visit Mayo Clinic: https://mayocl.in/2COVmlm Like Mayo Clinic on Facebook: / mayoclinic Follow Mayo Clinic on Instagram: / mayoclinic Follow Mayo Clinic on X, formerly Twitter: https://x.com/MayoClinic Follow Mayo Clinic on Threads: https://www.threads.net/@mayoclinic