Lecture On Fatty Acid Oxidation: Alpha, Omega & Unsaturated Pathways + Related Disorders | MBBS скачать в хорошем качестве

Lecture On Fatty Acid Oxidation: Alpha, Omega & Unsaturated Pathways + Related Disorders | MBBS

Explore the complex world of fatty acid metabolism beyond beta-oxidation in this in-depth video. We'll break down alpha oxidation, omega oxidation, and the oxidation of unsaturated fatty acids, while also examining significant disorders linked to these pathways. In this video, you will learn about: Understanding Key Disorders Related to Fatty Acid Metabolism: Sudden Infant Death Syndrome (SIDS): Discover the link between SIDS and a deficiency in medium-chain acyl-CoA dehydrogenase, impacting fat breakdown for energy. Jamaican Vomiting Sickness: Learn how consuming unripe ackee fruit, containing hypoglycin A, can block beta-oxidation and lead to severe hypoglycemia and other symptoms. Methylmalonic Acidemia: Understand this disorder related to odd-chain fatty acid metabolism, caused by deficiencies in vitamin B12 or methylmalonyl-CoA mutase, leading to methylmalonic acid buildup. Oxidation of Unsaturated Fatty Acids: Explore the specialized enzymes (isomerases and reductases) required to process fatty acids with double bonds and how this affects energy yield. Peroxisomal Beta-Oxidation: Learn about the beta-oxidation of very long-chain fatty acids (more than 20 carbons) that occurs in peroxisomes and how it differs from mitochondrial beta-oxidation. Zellweger Syndrome: Understand this disorder where peroxisomal beta-oxidation is blocked, leading to the accumulation of long-chain fatty acids in vital organs. Alpha Oxidation: Delve into this process that occurs at the alpha carbon, its role in removing one-carbon units, and how it differs from beta-oxidation (no ATP production). Refsum Disease: Examine this neurological disorder resulting from the accumulation of phytanic acid due to a deficiency in phytanic acid alpha-oxidase, and the origin of phytanic acid from chlorophyll. Omega Oxidation: Learn about this minor pathway involving hydroxylation and oxidation at the omega carbon of a fatty acid. Metabolic Water: Discover how the breakdown of fats can produce water, a crucial survival mechanism in certain animals. This video is ideal for students of biochemistry, metabolism, genetics, and medicine, providing valuable insights into less commonly discussed fatty acid oxidation pathways and their associated clinical conditions. TRIPURA SANTINIKETAN MEDICAL COLLEGE Real Class room Demonstration/Lecture On: (BIOCHEMISTRY) OMEGA & ALPHA OXIDATION BY-DR. JASMEET SINGH (MBBS Batch: 2024- 2025) Conducted on:- 17-03-25