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In the 21st century, the frontlines in the battle against tobacco will be low- and middle-income countries, according to Harvard Chan School Professor Howard Koh. In the 20th century, tobacco was linked to 100 million deaths—90% of which occurred in high-income countries, but in the 21st century it’s projected that there will be one billion tobacco-related deaths, with 70% occurring in low- and middle-income countries. A key factor is an increase in smoking among children and teens in those countries. According to the World Health Organization (WHO), 80,000–100,000 children worldwide start smoking every day. Nearly half of those who start smoking in their adolescent years will go on to smoke for 15 to 20 years. Koh says there has been progress, including the WHO’s Framework Convention on Tobacco Control, signed by 180 countries. Those countries agreed to take tobacco control measures ranging from limits on advertising to indoor smoking bans. Still, Koh says more needs to be done to protect children Howard Koh.