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Sperm Death in the Uterus

#fertilization #sperm #pregnancy MEDICAL ANIMATION TRANSCRIPT: Next, the sperm must pass through the cervix, an opening into the uterus. Usually it remains tightly closed, but here the cervix is open for a few days while the woman ovulates. The sperm swim through the cervical mucus, which has thinned to a more watery consistency for easier passage. Once inside the cervix, the sperm continue swimming toward the uterus, though millions will die trying to make it through the mucus. Some sperm remain behind, caught in the folds of the cervix, but they may later continue the journey as a backup to the first group. Inside the uterus, muscular uterine contractions assist the sperm on their journey toward the egg. However, resident cells from the woman’s immune system, mistaking the sperm for foreign invaders, destroy thousands more. Next, half the sperm head for the empty fallopian tube, while the other half swim toward the tube containing the unfertilized egg. Now, only a few thousand remain. Inside the fallopian tube, tiny cilia push the egg toward the uterus.To continue, the sperm must surge against this motion to reach the egg. Some sperm get trapped in the cilia and die. During this part of the journey, chemicals in the reproductive tract cause the membranes covering the heads of the sperm to change. As a result, the sperm become hyperactive, swimming harder and faster toward their destination.At long last, the sperm reach the egg. Only a few dozen of the original 300 million sperm remain. To learn more about Fertilization, watch:    • Fertilization   ANH12063S102