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Introduction to Olfaction (Lecture 1) by Dima Rinberg скачать в хорошем качестве

Introduction to Olfaction (Lecture 1) by Dima Rinberg 3 года назад

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Introduction to Olfaction (Lecture 1) by Dima Rinberg
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Introduction to Olfaction (Lecture 1) by Dima Rinberg

PROGRAM ICTP-ICTS WINTER SCHOOL ON QUANTITATIVE SYSTEMS BIOLOGY (ONLINE) ORGANIZERS: Vijaykumar Krishnamurthy (ICTS-TIFR, India), Venkatesh N. Murthy (Harvard University, USA), Sharad Ramanathan (Harvard University, USA), Sanjay Sane (NCBS-TIFR, India) and Vatsala Thirumalai (NCBS-TIFR, India) DATE: 06 December 2021 to 17 December 2021 VENUE: Online How organisms sense the world and generate behaviors is an exciting question that has motivated neuroscientists over more than a century. Neural command for generating behavioral output arises from operations at multiple scales, ranging from the flip-flops of ion channels to dynamics in circuits comprising ensembles of neurons. New tools to genetically manipulate organisms, monitor and perturb neural activity, and advanced microscopy that enables large scale imaging of neurons in vivo have yielded a hitherto unprecedented quantum of data with high resolution. Quantitative approaches are needed to mine these data sets for generating testable hypotheses regarding nervous system function. This is the tenth school in the series on Quantitative Systems Biology, held alternately at Trieste and Bangalore. The school responds to the strong need, especially at the Ph.D. and postdoc level, for providing scientists with a broad exposure to quantitative problems in the study of living systems. The audience will range from Ph.D. students to young faculty, who either work in this area or plan to do so. QSB2021 is focussed on Sensori-motor control. The aim of this School is to expose students from different backgrounds to the latest research in systems neuroscience, with an emphasis on the usage of quantitative methods and theory. We will begin the workshop with a brief introduction to neuroscience, including electrical properties of neuronal membranes and single neuronal biophysics. With this foundation in place, we will delve into how circuit dynamics emerge in diverse circuits using invertebrate and vertebrate model organisms as examples. We will cover questions in population coding, variability and stochasticity, and plasticity. We will then introduce students to applications of quantitative tools to neuroscience data sets such as whole-brain imaging data sets or behavioral clustering data sets. Throughout, we will also explore how theory can contribute to a normative understanding of various phenomena, and motivate future experiments. Scientists and students from all over the world can apply for the School. Researchers from developing countries are particularly encouraged to apply. As the program will be conducted in English, participants should have an adequate working knowledge of this language. There is no registration fee. SCIENTIFIC ORGANISING COMMITTEE 1. Venkatesh N. Murthy (Harvard University, USA) 2. Sharad Ramanathan (Harvard University, USA) 3. Sanjay P. Sane (NCBS, India) 4. Vatsala Thirumalai (NCBS, India) SCIENTIFIC ADVISORY COMMITTEE 1. Vijay Balasubramaniam (University of Pennsylvania, USA) 2. Upinder Bhalla (NCBS, India) 3. Antonio Celani (ICTP, Italy) 4. Sanjay Jain (University of Delhi, India) 5. Vijaykumar Krishnamurthy (ICTS, India) (Local organizer) 6. Matteo Marsili (ICTP, Italy) 7. Mukund Thattai (NCBS, India) Previous editions of this school 2020 2019 2018 2017 2016 2015 2014 2013 2012 CONTACT US: [email protected] PROGRAM LINK: https://www.icts.res.in/program/qsb2021 Table of Contents (powered by https://videoken.com) 0:00:00 Start 0:00:10 Introduction to Olfaction 0:03:23 Chemical senses: 0:10:08 One of human senses 0:14:44 Alexander Graham Bell (1914) 0:16:12 Human color vision 0:19:06 Olfaction 0:32:30 Chemical detection 0:34:07 Olfactory bulb 0:35:16 Mouse nose 0:38:43 Visualizing an Olfactory Sensory Map 0:39:26 The OR repertoire is mapped onto the olfactory bulb 0:45:59 Heterogeneity and Convergence of Olfactory First-Order Neurons Account for the High Speed and Sensitivity of Second-Order Neurons 0:53:18 Discovery of Neptune (September 24, 1846) 0:54:30 Dendrodendritic Synaptic Pathway for Inhibition in the Olfactory Bulb 1:03:12 Distinct representations of olfactory information in different cortical centres 1:14:12 R Carey, et. al., J. Neurophysiol. 2009 1:15:27 EEG Clin Neurophysiol 2: 377-388 (1950). 1:18:25 R Shusterman, et.al., Nature Neuroscience, 2011 1:21:48 Robust Odor Coding via Inhalation-Coupled Transient Activity in the Mammalian Olfactory Bulb 1:23:12 odor responses are temporally diverse 1:24:03 460 cell-odor pairs: 136 excitatory responses 1:26:10 Odor Representations in Olfactory Cortex: "Sparse Coding , Global Inhibition, and Oscillations 1:30:15 Q&A

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