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Cannabis is rapidly emerging as a preferred choice among individuals seeking relief for a myriad of health conditions, and its role in medical practice is expanding across Arizona and numerous states. As the adoption of cannabis as a therapeutic option grows, healthcare professionals must acquire essential competencies to navigate this evolving landscape effectively. In this enlightening video, we embark on a journey into the world of medical cannabis, exploring crucial aspects that healthcare practitioners and anyone interested in its therapeutic potential should include how cannabis affects our body and other health conditions through our endogenous cannabinoid system. Understanding therapeutic applications for which cannabis is indicated, while also discussing the various safety considerations for cannabis in a clinical environment. AzCANN is a 5-year cannabis education and outreach project. It is delivered by The University of Arizona Comprehensive Center for Pain & Addiction (CCPA) and funded by the Arizona Department of Health Services. This training was supported by grant number CTR063305 funded by the Arizona Department of Health Services (ADHS). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of ADHS.