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Mönckeberg's arteriosclerosis, also known as medial calcific sclerosis, is a type of arteriosclerosis characterized by the calcification of the middle layer of the arterial walls (tunica media). Here are some key points about this condition: Overview Cause: The exact cause is not fully understood, but it is associated with aging, diabetes mellitus, and chronic renal disease. Pathology: Unlike atherosclerosis, which involves plaque buildup within the arteries, Mönckeberg's arteriosclerosis involves calcification within the arterial walls without significant narrowing of the arterial lumen. Symptoms: Often asymptomatic, but in advanced cases, it can lead to reduced arterial elasticity and vascular stiffness, potentially causing symptoms like pain or cramping in the legs during physical activity (claudication). Diagnosis Imaging: Diagnosed through imaging techniques such as plain radiographs (X-rays), CT scans, and ultrasound, which show calcifications in the arterial walls. Ankle-Brachial Index (ABI): A test that compares blood pressure in the ankle with blood pressure in the arm to assess blood flow and detect peripheral artery disease. Clinical Significance Minimal Clinical Impact: Often considered a benign condition with minimal clinical impact due to the lack of significant arterial narrowing. Association with Other Conditions: It can coexist with other forms of vascular calcification and may be more pronounced in individuals with metabolic disorders #arteriosclerosis