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Dr Margo Mountjoy talks about the pathophysiology and evolution of Relative Energy Deficiency in Sport (RED-S). She discusses the implications of RED-S in terms of health and performance and how male athletes are affected. In addition to this, Dr Mountjoy proposes the RED-S clinical assessment tools for screening and return to play. The IOC Consensus and Clinical Assessment tools are available on the British Journal of Sports Medicine: (1) The IOC consensus statement: beyond the Female Athlete Triad—Relative Energy Deficiency in Sport (RED-S): http://bmj.co/1G22AuL (2) Authors’ 2015 additions to the IOC consensus statement: Relative Energy Deficiency in Sport (RED-S): http://bmj.co/1bEpu07 (3) RED-S CAT Tool: http://bmj.co/1xIwYcB Dr Margo Mountjoy is a member of the International Olympic Committee’s Medical Commission, is Chair of the FINA (Fédération Internationale de Natation) Sports Medicine Committee, and is a member of the World Anti-Doping Agency’s TUE (Therapeutic Use Exemption) Committee. Her areas of specialty include female athlete health, elite child athlete health, prevention of sexual harassment and abuse in sport, and anti-doping.