Quantitative Susceptibility Mapping on MRI as a Biomarker of Rebleeding in CASH скачать в хорошем качестве

Quantitative Susceptibility Mapping on MRI as a Biomarker of Rebleeding in CASH

Presentation Title: Quantitative Susceptibility Mapping on Magnetic Resonance Imaging (QSM MRI) as a Biomarker of Re-bleeding in Cavernous Angiomas with Symptomatic Hemorrhage (CASH) Session 2: Identification and Development of Novel Surrogate Endpoints for Use in Clinical Development Programs Speaker: Issam A. Awad, MD, MSc Summary: Cavernous angiomas (CA) or cerebral cavernous malformations (CCM) are clusters of dilated capillaries which are prone to hemorrhage that can either be symptomatic or asymptomatic. Cavernous angioma with symptomatic hemorrhage (CASH) is a rare disease and associated with higher likelihood of rebleed and significant co-morbidities. Researchers studied quantitative susceptibility mapping on magnetic resonance imaging (QSM MRI) as a biomarker for rebleeding over one year by measuring iron content of lesions. Researchers compared imaging results to ex vivo lesions and found that iron content matched that of imaging results in humans and in mouse models. Researchers also used QSM to measure the effect of atorvastatin on CASH in a proof-of-concept trial. Qualification of this imaging biomarker is in process. Key Takeaways: • Because not all hemorrhages are symptomatic, the identification of a stable biomarker to identify asymptomatic hemorrhage was needed • Non-heme iron mineralization was identified as a potential imaging biomarker • Validation in human and mouse models showed excellent sensitivity to symptomatic and asymptomatic rebleeding in lesions • Currently being assessed in a single site, proof of concept trial and pending favorable results it may be applied to other trials