Prof. Ellen Roche, Integrating Organic Components with Synthetic Soft Robots скачать в хорошем качестве

Prof. Ellen Roche, Integrating Organic Components with Synthetic Soft Robots

Integrating Organic Components with Synthetic Soft Robots; a Paradigm Shift for Preclinical Testing of Implantable Devices Prof. Ellen Roche is the W.M Keck Foundation Career Development Assistant Professor at the Institute for Medical Engineering and Science and the Department of Mechanical Engineering at the Massachusetts Institute of Technology (MIT). She directs the Therapeutic Technology Design and Development Lab. She completed her PhD at Harvard University School of Engineering and Applied Sciences. Her research focuses on applying innovative technologies to the development of medical devices. Her research includes development of novel devices to repair or augment cardiac function using disruptive approaches such as soft robotics, combination of mechanical actuation with delivery of cell therapy, and use of light activated biodegradable adhesives. Prof. Roche was employed in the medical device industry for over five years as a research and development engineer and employs her understanding of the medical device industry and the regulatory pathways to medical device commercialization in her academic research. She holds 5 issued patents, with ten pending and is the authors of over 40 conference/journal papers. She is the recipient of multiple awards including the Fulbright International Science and Technology Award, the Wellcome Trust Seed Award in Science, an American Heart Association Pre-Doctoral Award, a National Science Foundation CAREER Award and a Charles H. Hood Award for Excellence in Child Health Research. Abstract Preclinical testing of implantable medical devices that function in dynamic environments is typically conducted in simplified in vitro models before moving to animal models. There is an unmet need for high fidelity physical testbeds to bridge the gap between these two preclinical models. In this talk I will discuss hybrid biorobotic matrices that are designed to recapitulate pulmonary and cardiac biomechanics in vitro. I will describe how we exploit advancements in soft actuator technology to build soft active anthropomorphic matrices that can replicate diaphragmatic and cardiac muscle to drive lung ventilation and hemodynamic circulation respectively. First, I will discuss how a soft robotic diaphragm is programmed to mimic clinical motion, and when integrated into a simulator with abdominal and thoracic chambers subjected to physiological pressures, can drive preserved ex vivo lung inflation and deflation. Next, I will describe a bioinspired soft robotic heart that preserves the anatomical intracardiac structures but is powered by synthetic, soft robotic myocardium (heart muscle) which will drive blood flow in an instrumented circulatory flow loop. Finally, I will discuss the integration of both systems into a modular simulator platform with dynamic, anthropomorphic heart, lungs and diaphragm. As an exemplary configuration of this technology, I will describe how we simulate the Fontan physiology - a surgically corrected pediatric cardiac condition that affects both the cardiovascular and respiratory systems. This organosynthetic simulator combines robotics with biological tissue for increased biofidelity and has vast utility in quantitative research and development, device testing and as a hands-on, interactive visualization platform for enhanced medical training and pedagogy.